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Joint Meeting- ACS Philadelphia Section & Chemical Consultants Network

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Wednesday February 13, 2019 5:30 PM - 8:30 PM

Special Deal for

Undergraduate STEM Students

YCC and Senior Chemists Philadelphia ACS


If you are a graduate or undergraduate in Chemistry, we are inviting you to attend this event.

Registration will be reimbursed by a grant from the Senior Chemists. Email Prof. Michael J.

Castaldi for details


 When

13 Feb 2019


 5:30 PM - 9:00 PM


 Location

The Cynwyd Club, 332 Trevor Lane, Bala Cynwyd, PA 19004


Fee, including dinner and non-alcoholic beverages, is $30 by reservation/cancellation

deadline: Saturday, Feb. 9th, 2019.


 Attendee – $30.00

 Attendee (Talk only, no dinner)


Joint Meeting- ACS Philadelphia Section & Chemical Consultants Network


Patrick Y.S. Lam – Distinguished Professor, Baruch S. Blumberg Institute

DATE & TIME: Wednesday, Feb. 13th at The Cynwyd Club, Bala Cynwyd, PA

Networking, 5:30 PM; Dinner, 6:30 PM; Talk and Business Session, 7:30 PM

Abstract: Thrombosis is the leading cause of death in developed countries, generating a

significant need for novel antithrombotics with an improved safety profile. Utilizing Structure-

Based-Drug-Design tools, focused screening, and ADME-T innovations, BMS/DuPont

discovered a novel class of potent, selective and orally bioavailable Factor Xa inhibitors

culminating in Eliquis®/Apixaban, with current annual sales of >$5B. In 2015, the Eliquis

discovery team received the ACS Heroes of Chemistry Award. During the optimization

process, they also codiscovered the powerful Chan-Lam Coupling reaction of copper

promoted C-element bond coupling via boronic acids, a complementary reaction to the Nobel

prize-winning Suzuki-Miyaura C-C bond Coupling reaction. At the molecular recognition

frontier, they pioneered the first rational use of halogen bonding in SBDD.