Special Deal for
Undergraduate STEM Students
YCC and Senior Chemists Philadelphia ACS
If you are a graduate or undergraduate in Chemistry, we are inviting you to attend this event.
Registration will be reimbursed by a grant from the Senior Chemists. Email Prof. Michael J.
Castaldi for details
13 Feb 2019
5:30 PM - 9:00 PM
The Cynwyd Club, 332 Trevor Lane, Bala Cynwyd, PA 19004
Fee, including dinner and non-alcoholic beverages, is $30 by reservation/cancellation
deadline: Saturday, Feb. 9th, 2019.
Attendee – $30.00
Attendee (Talk only, no dinner)
Joint Meeting- ACS Philadelphia Section & Chemical Consultants Network
DISCOVERY OF A BLOCKBUSTER DRUG AND CHAN-LAM COUPLING REACTION
Patrick Y.S. Lam – Distinguished Professor, Baruch S. Blumberg Institute
DATE & TIME: Wednesday, Feb. 13th at The Cynwyd Club, Bala Cynwyd, PA
Networking, 5:30 PM; Dinner, 6:30 PM; Talk and Business Session, 7:30 PM
Abstract: Thrombosis is the leading cause of death in developed countries, generating a
significant need for novel antithrombotics with an improved safety profile. Utilizing Structure-
Based-Drug-Design tools, focused screening, and ADME-T innovations, BMS/DuPont
discovered a novel class of potent, selective and orally bioavailable Factor Xa inhibitors
culminating in Eliquis®/Apixaban, with current annual sales of >$5B. In 2015, the Eliquis
discovery team received the ACS Heroes of Chemistry Award. During the optimization
process, they also codiscovered the powerful Chan-Lam Coupling reaction of copper
promoted C-element bond coupling via boronic acids, a complementary reaction to the Nobel
prize-winning Suzuki-Miyaura C-C bond Coupling reaction. At the molecular recognition
frontier, they pioneered the first rational use of halogen bonding in SBDD.